The pharmacological management of erectile dysfunction

  • AndrĂ© Marais University of Pretoria
Keywords: cardiovascular disease, erectile dysfunction, phosphodiesterase-5 inhibitors, prostaglandin, testosterone


The inability to attain or maintain a penile erection sufficient for sexual intercourse is a common problem experienced by a third of men over the age of 40 years. Erectile dysfunction (ED) is a debilitating disease which can have profound psychological effects on personal relationships and the social well-being of the affected individual. The diagnosis and evaluation of sexual dysfunction has been well described, and several validated algorithms are available to quantify the classification and severity. The International Index of Erectile Function and the Sexual Health Inventory for Men questionnaires are commonly used in the initial assessment of ED. Several risk factors have been linked to the pathophysiology of ED. Endothelial damage has been the focus of many recent studies. An evaluation of cardiovascular status, in addition to the administration of questionnaires to men with ED, might reduce mortality and improve sexual quality of life.

Author Biography

André Marais, University of Pretoria
BPharm, MBChB, MSCPharm Senior Lecturer and Clinical Pharmacologist Department of Pharmacology School of Medicine Faculty of Health Sciences University of Pretoria
Review Articles