• Willie Frederick Mollentze University of the Free State


Most clinicians are familiar with acanthosis nigricans, a dermatosis, characterised by brownish-black velvety, papilomatous hyperkeratotic plaques, usually occurring in the neck, axillae and other intertriginous surfaces.1 Acanthosis nigricans is most frequently associated with insulin-resistant states, such as type 2 diabetes, polycystic ovarian disease and a variety of endocrine disorders.2 Less commonly, acanthosis nigricans is also associated with internal malignancies, such as carcinoma of the colon,3 and in the setting of niacin use, in the management of dyslipidaemia.4

Author Biography

Willie Frederick Mollentze, University of the Free State
Professor and Head Department of Internal Medicine University of the Free State