A pelvic paraganglioma presenting as a hypertensive emergency in pregnancy

  • Fredricka Johanna Bosch University of the Free State
  • Jacqueline Goedhals University of the Free State and National Health Laboratory Service
  • Wimpie de Lange University of the Free State
  • A Michael Ackerman University of the Free State
  • Johanna Maria Magdalena Koning University of the Free State
Keywords: paraganglioma, pregnancy, hypertension

Abstract

Paraganglia are neuroendocrine organs that originate from the neural crest cells that are closely associated with the autonomic nervous system.1 Paragangliomas and phaeochromocytomas are tumours that arise from these organs. Paragangliomas are extra-adrenal tumours that can be divided into sympathetic and parasympathetic, and are further categorised by site.1 The term “phaeochromocytoma” is reserved for intra-adrenal tumours. The most common location of these extra-adrenal paragangliomas is the inferior para-aortic region (also known as the organ of Zuckerkandl).1 Other extra-adrenal sites that have been described include the bladder, pelvis, prostate, ovaries and thorax.1 According to McNicol, the estimated incidence of paragangliomas is 1:300 000. At least 30% of paragangliomas have a hereditary occurrence. Approximately 10% are syndromic.1 We describe a case of extra-adrenal pelvic paraganglioma that caused hypertension in pregnancy.

Author Biographies

Fredricka Johanna Bosch, University of the Free State
MBChB, MMed (Int Med) Specialist Division of Endocrinology Department of Internal Medicine University of the Free State
Jacqueline Goedhals, University of the Free State and National Health Laboratory Service
MBChB, MMed(Anatomical Pathology), DTM&H, MScMedSci (Cytopathology) Senior Specialist Department of Anatomical Pathology University of the Free State and National Health Laboratory Service Bloemfontein
Wimpie de Lange, University of the Free State
MBChB, MMed (Int Med), (Endocrinology) Sub-Specialist Division of Endocrinology Department of Internal Medicine University of the Free State
A Michael Ackerman, University of the Free State
MBChB, DA(SA), MMed (Anaesthesiology) Sub-Specialist Department of Anaesthesiology University of the Free State Bloemfontein
Johanna Maria Magdalena Koning, University of the Free State
MBChB, MMed (Int Med), (Endocrinology) Principal Specialist Division of Endocrinology Department of Internal Medicine University of the Free State
Published
2012-08-06
Section
Case Study